|
KMID : 1137820200410010062
|
|
의공학회지
2020 Volume.41 No. 1 p.62 ~ p.66
|
|
|
Stereocomplex Poly(lactic acid) Discoidal Microparticles for Sustained Drug Release
|
|
Park Chae-Won
Park Sang-Hyo
Kim Woo-Cheol
Key Jae-Hong
|
|
|
Abstract
|
|
|
|
Controlled drug release is important for effective treatment of cancer. Poly(DL-lactide-co-glycolide) acid (PLGA) is a Food and Drug Administration (FDA) approved polymer and have been extensively studied as drug delivery carriers with biodegradable and biocompatible properties. However, PLGA drug delivery carriers are limited due to the initial burst release of drug. Certain drugs require an early rapid release, but in many cases the initial rapid release can be inefficient, reducing therapeutic effects and also increasing side effects. Therefore, sustained release is important for effective treatment. Poly Lactic Acid stereo complex (PLA SC) is resistant to hydrolysis and has high stability in aqueous solutions. Therefore, in this work, PLGA based discoidal polymeric particles are modified by Poly Lactic Acid stereocomplex (PLAsc DPPs). PLAsc DPPs are 3 μm in diameter, also showing a relatively sustained release profile. Fluorescein 5(6)-isothiocyanate (FITC) released from PLAsc DPPs was continuously observed until 38 days, which showed the initial release of FITC from PLAsc DPPs was about 3.9-fold reduced as compared to PLGA based DPPs at 1 hour.
|
|
|
KEYWORD
|
|
|
Drug delivery, Carriers, PLA stereo complex, Sustained release
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|